Inflammatory phase (0-72 hours): Immediately after the injury, histamine secretion increases and the surrounding vessels dilate and blood flow to the area accelerates. After the increase in blood in the injured area, transudate occurs, bradykinin and prostaglandin are secreted through histamine. In this way, vasodilation is provided in the region, the pain receptors in the region are sensitized and the region is protected. After this response, temperature increase, edema, pain, redness are seen. After this reaction response, first of all, the neurophiles are released and clean the small-scale destroyed cells in the injured area. Later, monocytes become activated and turn into macrophages, and large-scale destroyed cells in the area are cleared. The acid secreted from macrophages makes the blood fluid and makes it a single unit. It also reduces the subcutaneous fat tissue and causes the skin to appear thin and shiny. After fibrin formation, fibrin plaques block the lymphatic channels leading to that area and prevent the dispersal of inflammation in the region.

Repair (proliferation) phase (48 hours-6 weeks): After the destroyed tissue in the area is cleaned by macrophages, growth factors (PDGF, TGF, FGF) are secreted by macrophages. After the secretion of these substances, collagen production begins through fibroblasts, and first of all, fibronectin and type 3 collagen production takes place. 5-7 in one study. There is maximum type3 collagen production between days 2-3. reaches its maximum amount at the end of the week. In another study, this production was found in parallel with the nitric oxide formation level and days in the tissue. If the necessary treatment is not applied during this period or if the immobilization period is kept long, tissue adhesions occur after fibrin precipitation. this stage is divided into parts: epithelialization, fibroplasia, angiogenesis, collagen synthesis.

Remodeling(3 weeks-1 year): After the 6th week, type 3 collagens begin to transform into type 1 collagen, thus creating a more robust tissue. In this phase, blood supply and revascularization (angiogenesis) occur. this formation occurs as a result of intermittent pressures on the tissue.

Inflammatory phase (0-72 hours): Immediately after the injury, histamine secretion increases and the surrounding vessels dilate and blood flow to the area accelerates. After the increase in blood in the injured area, transudate occurs, bradykinin and prostaglandin are secreted through histamine. In this way, vasodilation is provided in the region, the pain receptors in the region are sensitized and the region is protected. After this response, temperature increase, edema, pain, redness are seen. After this reaction response, first of all, the neurophiles are released and clean the small-scale destroyed cells in the injured area. Later, monocytes become activated and turn into macrophages, and large-scale destroyed cells in the area are cleared. The acid secreted from macrophages makes the blood fluid and makes it a single unit. It also reduces the subcutaneous fat tissue and causes the skin to appear thin and shiny. After fibrin formation, fibrin plaques block the lymphatic channels leading to that area and prevent the dispersal of inflammation in the region.

Repair (proliferation) phase (48 hours-6 weeks): After the destroyed tissue in the area is cleaned by macrophages, growth factors (PDGF, TGF, FGF) are secreted by macrophages. After the secretion of these substances, collagen production begins through fibroblasts, and first of all, fibronectin and type 3 collagen production takes place. 5-7 in one study. There is maximum type3 collagen production between days 2-3. reaches its maximum amount at the end of the week. In another study, this production was found in parallel with the nitric oxide formation level and days in the tissue. If the necessary treatment is not applied during this period or if the immobilization period is kept long, tissue adhesions occur after fibrin precipitation. this stage is divided into parts: epithelialization, fibroplasia, angiogenesis, collagen synthesis.

Remodeling(3 weeks-1 year): After the 6th week, type 3 collagens begin to transform into type 1 collagen, thus creating a more robust tissue. In this phase, blood supply and revascularization (angiogenesis) occur. this formation occurs as a result of intermittent pressures on the tissue.